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La depuracin de este frmaco disminuye significativamente en pacientes con enfermedad renal crnica en hemodilisis ya que su eliminacin es principalmente por filtracin glomerular, por lo que no est recomendada en pacientes con depuracin de creatinina 30 ml/min), pero debe monitorearse una posibilidad de mayor incidencia de efectos adversos gastrointestinales y renales, mientras que debido a la falta de datos en pacientes con enfermedad renal terminal, no se recomienda su uso 69,70

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Bone 50, 156160.10.1016/j.bone.2012.02.488 280 OswiecimskaJ.ZioraK.AdamczykP.RoczniakW.Pikiewicz-KochA.StojewskaM.et al (2007)