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10.1093/astrogeo/atx025 Astron

The second stage is completed by glutathione synthetase (GS), whose substrate -Glu-Cys undergoes peptide bond condensation with glycine, accompanied by the hydrolysis of ATP to provide the required reaction energy

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It remains to be determined whether boosting complimentary routes with exogenous substrates, such as citrate, or genetic/pharmacological interventions to increase ME1 or IDH1 levels and/or activity, is sufficient to counteract the excessive oxidative stress and hemolysis seen in G6PD def erythrocytes