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This dehydration can also increase the risk of kidney injury, especially in those with pre-existing kidney conditions

However, no significant correlations were found between insulin resistance and migraine frequency, duration, or severity

An additional 202 articles were excluded for the following reasons: irrelevant study population (n=60), unrelated interventions (n=90), insufficient or incomplete data (n=52), and language limitations (non-English)

Retatrutide takes this idea further by adding a third target