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13 This patient had psoriasis plaques that were refractory to topical therapies and adalimumab, as well as T2DM that was poorly controlled with metformin therapy

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This study demonstrated for the first time that disturbed NAD+ metabolism accelerates follicular atresia and ovarian reserve depletion by disrupting the microenvironment of oocytesomatic cell interactions, ultimately leading to a reproductive ageing phenotype [82]

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