[73] Sakao K, Vyas A, Chinni S, et al
ReACp53, designed by Soragni et al., is a peptide that suppresses mutant p53 aggregation, restores the wild-type conformation of mutant p53, and promotes its nuclear localization to increase its transcriptional activity
SNPs sometimes play a more significant role by directly affecting a genes function
However, incorrect concentrations or excessive dosage levels can disrupt baseline circadian rhythms and cause short-term lethargy patterns
In addition, the transcription of the IGF-2 gene is similarly reduced by wild-type p53 (Zhang et al, 1996)
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