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Gastroenterology 129 , 14301436 (2005)

Post mortem evaluation of inflammation, oxidative stress, and PPARgamma activation in a nonhuman primate model of cardiac sympathetic neurodegeneration

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They also play a role in the "gut-brain axis," a two-way communication line between the digestive system and the central nervous system

Among those with obesity, GLP-1RA users demonstrated a 47% reduced risk of pancreatic cancer versus insulin users, and a 19% lower risk compared to those taking SGLT2 inhibitors

Key considerations include: Lack of standardized dosing guidelines Limited long-term safety data Variability in manufacturing quality Anyone considering experimental therapies should do so under appropriate medical guidance