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5 Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA

The peptide is now a passenger on a 66 kDa carrier protein with a plasma half-life of about three weeks

TB-500 has been shown to promote cell migration, angiogenesis, cytoskeletal reorganization, and anti-inflammatory signaling in preclinical models 1,2

A rise in stress hormones such as cortisol and adrenaline 17

These issues affect the core evidence base for Dihexa's claimed mechanism and efficacy

Metabolic heterogeneity, plasticity, and adaptation to glutamine addiction in cancer cells: the role of glutaminase and the GTA [glutamine transaminase-amidase (glutaminase II)] pathway