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Patients with genetic variants associated with reduced B12 absorption or increased metabolic demand often benefit most from methylcobalamin (more bioavailable) or intramuscular administration, rather than standard oral cyanocobalamin

It is that simple

Simply put, its the fact that its currently illegal to obtain as well as to use for clinical studies, meaning it cannot be studied for its benefits or side effects

NHS and NICE guidance on weight management focus on sustainable dietary changes, physical activity, and behavioural support rather than supplement timing

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