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For statistical modelling, the lmer and summary function of the lmerTest package v3.1.3 68 was used which estimates degrees of freedom using the Satterthwaite approximation

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Call 999 or go to your nearest A&E immediately if you experience any signs of a severe allergic reaction (anaphylaxis), including: Swelling of the face, lips, tongue, or throat Difficulty breathing or swallowing Dizziness, collapse, or a sudden drop in blood pressure A rapidly spreading rash with any of the above symptoms For urgent advice when you are unsure or cannot reach your trial coordinator, call NHS 111 (available 24 hours a day)