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found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)

The GPCR heterotetramer: challenging classical pharmacology

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Numerous cohort studies have confirmed that higher adherence to the MIND diet is associated with slower cognitive aging, reduced incidence of AD, and even protection against Parkinsonian syndromes (Wodarek, 2019)

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