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This approach can be used alone or in tandem with GLP-1 agonists

107 Further, a study found that after T2D patients had bariatric surgery, GLP-1R expression in adipose tissue did not affect metabolic outcomes such as insulin sensitivity improvement, T2D remission and weight loss

If that happens, it may be worth considering some of the other medications approved for weight loss that are not GLP-1s

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These findings suggest a broader role for glucose in pain modulation, which may inform potential therapies targeting both metabolic and pain pathways

Some of the best options include: Berberine