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Dual modifications, such as 2,4- and 2,5-sugar modifications, have been employed in the development of siRNA therapeutics to further expand the potential of ribose modifications

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Among these pathways, Alzheimer disease, Serotonergic synapse, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS), Glutamatergic synapse, Cholesterol metabolism, Long-term potentiation, Phagosome, Immune system, and TNF signaling pathway belong to at least two perspectives (Fig

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