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[PubMed: 15047650] 382

Membranes were pretreated with 5% non-fat milk/TBST (1 h) before overnight exposure at 4 C to antibodies targeting MAPKAPK2 (ab32567), HO-1 (ab189491), KEAP1 (ab119403), Nrf2 (ab137550), -H2AX (ab81299), PARP-1 (ab191217), CHK2 (ab207446), phosphorylated CHK2 (p-CHK2, ab59408), TYR (ab170905), PMEL (ab137078), MITF (ab12039), p-HSP27 (ab155987), HSP27 (ab12351), -actin (ab8226), and Histone H3 (ab1791) (all from Abcam, UK)

Compared with the group administered with DEX/SERT, there was an increase in GPx with DEX/SILY 140, DEX/SILY 280, DEX/SERT/SILY 140, and DEX/SERT/SILY 280

Tilting the redox balance towards oxidative stress in nucleated cells, i.e., by increasing the ROS levels, normally leads to cell death (apoptosis) or to an acceleration in ageing [111]

This can lead to serious problems

doi: 10.3389/fendo.2023.1095753 Received 11 November 2022 Accepted 08 February 2023 Published 22 February 2023 Volume 14 - 2023 Edited by Xiaodong Sun, Affiliated Hospital of Weifang Medical University, China Reviewed by Raffaele Carraro, La Princesa University Hospital, Spain