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The study also examines whether synergies or trade-offs exist between these capacities

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Critical clarification: These results come from clinical trials of FDA-approved branded medications conducted under controlled conditions with specific patient populations

The meta-regression failed to show any individual covariate that had statistically significant moderating effect on the pooled effect size

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348 Notably, CDK4/6 inhibitors have been shown to increase the tumor immune response and TILs, 362,363 which supports the potential synergistic effects of CDK4/6 inhibitors and ICIs