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However, its role in glucagon secretion is more complex, with some evidence suggesting it may stimulate glucagon release during hypoglycemia

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Furthermore, conditions primarily influenced by ferroptosis can be mitigated by focusing on the regulation of iron homeostasis (utilizing iron chelators), as well as by modulating lipid and amino acid metabolic pathways

The activation of the aforementioned non-canonical TGF--mediated signaling cascades have been implicated in the pathogenesis of fibrosis and fibrotic diseases including renal fibrosis, liver fibrosis, systemic sclerosis and osteoarthritis (107, 108)