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Previous work has shown that knockdown of the mitochondrial electron transport chain (ETC) subunit cco-1 in neurons can induce the UPR mt in distal cell types

Nevertheless, it is possible that the two processes influence one another

In vitro experiments using human dermal fibroblast cultures are common for quantifying the peptide's impact on the synthesis of collagen, elastin, and other extracellular matrix proteins

Erythrocytes dont have the intrinsic apoptotic machinery upstream of caspase-3, including cytochrome c or apoptotic peptidase-activating factor 1 (APAF-1) [22, 23]