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Most of the current evidence comes from rodent models, whose pathophysiological processes differ from those of human DKD, and most of the existing studies focus on intervening in early lesions, and their pharmacological effects in reversing structural damage, such as glomerulosclerosis in advanced DKD, remains to be verified

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Instead of puncturing the same stopper 30 or 40 times over a month, you puncture each smaller vial only a few times