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Some patients benefit from combination T4/T3 therapy, though evidence supporting superiority over levothyroxine monotherapy is limited

These fluctuations can lead to increased sensitivity in the heart's electrical system, resulting in more frequent palpitations

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STEP-1: Semaglutide 2,4 mg, the standard since 2021 The STEP-1 trial (Wilding et al., NEJM 2021, PMID 33567185) randomized 1,961 overweight or obese adults (BMI 30 or BMI 27 with comorbidities) without diabetes to semaglutide 2,4 mg/week or placebo, with lifestyle interventions administered concurrently in both arms