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Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration

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Patients should avoid injecting into areas where the skin is broken, bruised, scarred, or affected by skin conditions such as psoriasis or eczema

You can titrate in 0.125 mg increments rather than jumping from 0.25 mg to 0.5 mg or from 1 mg to 1.7 mg

10.1038/s41598-017-13722-4 97

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