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The Philippine FDA, the Philippine Dermatological Society, and the Dermatological Society of Singapore have issued advisories against using IV glutathione for skin lightening [60]

Both free Rifs solution and Rif-SLNs exhibited MIC values of 8 g/mL and 4 g/mL, respectively, suggesting the superior effectiveness of Rif-SLNs compared to free rifampicin

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So, while the mechanism is persuasive, it is not quite at the level of, say, well-known medications that affect metabolism

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And so it needs to be near the site of injury