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In the questionnaires, the following features/items were addressed: skin lightening, facial skin evenness, pigmented spots lightening, pore size improvement, skin smoothness, wrinkle reduction crows feet, wrinkle reduction nasolabial folds, wrinkle reduction forehead, general skin condition, fatigability, sleep (e.g., quality and length) Safety To evaluate the safety of subjects, vital signs were determined at each visit

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