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Days 11-14: Tail-Off and Early Washout The first 3-4 days after the last injection are not "off-cycle" in any biological sense

For women dealing with PCOS-related obesity, these changes can be incredibly motivating, encouraging them to continue treatment despite occasional gastrointestinal discomfort

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Most people describe the nausea as manageable, similar to mild motion sickness

Weight reduction: In the phase 2 trial, cagrilintide 4.5 mg weekly produced approximately 10.8% body weight loss over 26 weeks versus 3.0% with placebo [4]

For most people, these are most pronounced when they first start the medication or after a dose increase