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The FDA does not approve dietary supplements before they go on sale

Zepbound (tirzepatide) injection, for subcutaneous use

Proglucagon, a precursor polypeptide, undergoes tissue-specific post-translational processing to yield various biologically active peptides in the pancreas and the gut/brain

Since then, Novo Nordisk (Wegovy and Ozempic) and Eli Lilly (Mounjaro and Zepbound) have struggled to manufacture enough product and both of Novo Nordisk's semaglutide medications have been on the FDA's shortage list since early 2022

Success depends on preparing for the return of appetite, keeping healthy habits, and setting realistic expectations about possible weight regain

Some employer plans still exclude weight loss medications entirely