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1,2 No increase in serious heart events (heart attack, stroke) has been reported, but a dedicated cardiovascular outcomes trial is still pending

A major challenge in MSTN inhibition is the potential for off-target effects, as other TGF- family ligands, such as GDF11, activins, and BMPs, share the same receptor.[81] Thus, blocking MSTN may unintentionally disrupt other critical signaling pathways

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