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BMS is implementing cost-cutting plans with recently appointed CEO Christopher Boerner adding $2bn in cuts in 20252027 toa $1.5bn plan already in place since last year

It can occur because of AGEs engagement in the production of reactive oxygen and nitrogen species, and also accompany oxidative stress and inflammation

These chelating agents function by forming complexes with iron

In addition, an induction after cytokine stimulation was described which is often mediated by the transcription factors NF- B and STAT3 [26, 27, 134]

Systems Biology of Free Radicals and Antioxidants

However, its effect is still controversial, and its mechanism is not clear