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In vitro, ChaC1 induces cell death in KIRC cell lines, signifying its potential as an effective marker for poor prognosis in KIRC (70)

GLP-1Rs are widely expressed in the whole body including the kidney [1, 10,11,12,13,14,15] and GLP-1 has diuretic and natriuretic effects in humans and animal models of hypertension, diabetes and obesity [10, 12, 13, 16]

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