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Local IGF-1 expression enhances muscle regeneration and reduces inflammation following injury. Musar, A

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In addition, marked fluctuations in leptin and other hormonal secretion patterns throughout the different endocrine states during the female lifespan (Including puberty, pregnancy, and menopause) have been linked with changes in the regulation of the innate and adaptive immune systems, and disbalance between pro and anti-inflammatory states, which altogether increase the risk of developing autoimmune diseases (22, 24)

CDH1 encodes E-cadherin, a transmembrane glycoprotein involved in cellcell adhesion which is regulated by the key transcription factor GRHL2 [95,96,97]