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As a key antioxidant transcription factor, NRF2 activity decreases during heart failure, while miRNAs modulate NRF2 and its associated antioxidant proteins through EV, thereby regulating oxidative stress [166]

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Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clinical, cosmetic and investigational dermatology 7 (2014): 267.