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The profound anatomical and pathophysiological disparities between these models and human disease create a significant translational gap. Acknowledging these limitations is key to interpreting preclinical data cautiously and designing more relevant experimental paradigms

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We searched Buchnera proteomes for candidate effectors, leading us to focus on an uncharacterized gene encoding a hypothetical protein with few homologues outside Buchnera

Significant weight loss with appropriate reduction in fat mass measured via CT scans was observed in healthy volunteers with moderate to severe overweight when receiving over 12 weeks either two times per d 4 g or 7 g of allulose provided by test drinks (Reference Han, Kwon and Yu40)