The medication is effective when used as part of a comprehensive weight management plan
Abbreviations CKD: Chronic kidney disease DKA: Diabetic ketoacidosis FDA: US Food and Drug Administration GLP-1 RA: Glucagon-like peptide-1 receptor agonist HCO: Healthcare organisation IHD: Ischaemic heart disease PSM: Propensity score matching SGLT2i: Sodium-glucose cotransporter 2 inhibitor SSMD: Strictly standardised mean difference UTI: Urinary tract infection References Gregory GA, Robinson TIG, Linklater SE et al (2022) Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study
low-dose tricyclic antidepressants (e.g., amitriptyline 10mg at night, with gradual titration) for pain and altered motility For IBS-C : Laxatives such as macrogols (polyethylene glycol)
These benefits are not guaranteed
Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
Food and Drug Administration (FDA) in 2022 under the brand name Mounjaro, Tirzepatide represents a new class of diabetes treatment that works differently from traditional drugs