These reactions often act to detoxify drugs (although in some cases the intermediates in drug metabolism may cause toxic effects)
In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation
A clustering of contamination events or persistent post-inflammatory hyperpigmentation cases tied to specific at-home protocols would shift the recommendation toward more conservative cadence or stricter contraindication screening
doi:10.1186/s12951-023-02222-5 133
Larger and longer-term clinical trials are needed, and supplementation with other compounds important for methionine metabolism, such as vitamin B6, should be considered in ALD patients
doi: 10.3390/molecules26030702 71 JohnsonJBHungerfordNLSultanbawaYNetzelME
