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fewer than 1% require treatment discontinuation Persistent heartburn beyond 16 weeks at stable dosing may indicate unmasked GERD rather than medication-induced reflux and warrants provider evaluation Direct answer (40-60 words) Zepbound (tirzepatide) causes heartburn by slowing how quickly your stomach empties food

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[15] Always follow dosing instructions and consult your pharmacist if you have questions about appropriate pain relief options