sounds dumb but its nice Karen D., 52, Montreal QC Weeks 25-36 Summary: Patience Pays Off Weight loss: 4-8 pounds this period (42-46 pounds total, ~21% of starting weight) Weekly loss rate: Averages 0.3-0.7 pounds weekly (significantly slower but still progressing) Body composition: Often improving more than scale suggests Discontinuation rate: 2-3% stop during this period, usually from frustration with slowing progress Psychological state: Requires intentional perspective maintenance Key achievement: Persisting through plateau without giving up or making counterproductive changes Weeks 37-48: The Plateau Phase (12mg Maintenance) Starting Weight Week 37: ~174 pounds | Expected Weight Week 48: 167-171 pounds | Net Loss This Period: 3-7 pounds | Total Loss: 49-53 pounds Whats Happening Physiologically Approaching maximum effect of Retatrutide at 12mg weekly dose
Make sure you are consistently hitting a reasonable daily protein target
In a 48-week trial of 338 adults with obesity, participants randomized to the 12 mg dose achieved a mean weight loss of 24.2%, which equated to approximately 26.2 kg for a person at a high starting weight
Improved Glycemic Control: GIP receptor activation enhances insulin sensitivity, while glucagon receptor activation promotes fat oxidation, making these agents effective for adolescents with both obesity and insulin resistance
Alcohol irritates the stomach lining, increases gastric acid production, and has its own direct effects on nausea centers in the brain
Strong-smelling foods trigger the olfactory-nausea connection that makes hot foods problematic
