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This gradual accumulation of damage, particularly in the form of small, deep brain infarcts known as lacunar infarcts, is a common pathway through which ischemic strokes lead to VaD 62

The study involved 130 ALS patients (74 men and 56 women) whose symptoms began within one year of enrollment and who progressed at a moderate rate, defined as a 12 point decrease in their ALSFRS-R scores over the three months preceding the trial

Because homocysteine reflects how efficiently the methylation cycle is functioning, measuring and managing homocysteine levels can provide valuable insights into overall health and may help identify opportunities for early nutritional intervention

doi: 10.1007/s00726-007-0598-9