In the STEP clinical trial program evaluating Wegovy for weight management, participants achieved mean weight reductions of 12% to 15% of baseline body weight over 68 weeks, significantly exceeding results seen with lifestyle modification alone
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Comprehensive assessments should also include screening for pregnancy where relevant, eating disorders, renal function, HbA1c (especially if diabetic or at risk), lipid profile, thyroid function, gallbladder/pancreatitis history, and potential drug interactions
These changes likely result from metabolic shifts and weight loss rather than direct hormonal effects
For those concerned about potential long-term side effects, Hughes notes that while GLP-1 drugs are new players in combating obesity, theyve been around for 20 years for diabetes management
