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for instance, IL-1 activates the Mitogen-Activated Protein Kinase (MAPK) pathway to enhance serotonin transporter (SERT) activity, leading to decreased synaptic 5-HT concentrations and thereby further inducing depressive-like behaviors (Zhu et al., 2010)

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proteome and metabolome profiling of aged muscle tissue

Potential toxicity includes adverse reactions such as serotonin toxicity, especially in patients taking serotonergic drugs

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Management strategies depend on disease extent and severity