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BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks

However, mutations in the MTHFR gene typically result in a lack of folate required for methylation reactions

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Knockdown of p62, NQO1, HO-1 and ferritin heavy chain 1 through RNA interference exacerbates erastin-induced ferroptosis (42,43)