retatrutide mechanism glp-1 gip glucagon triple agonist review 2024 2025 What is the pipeline for future medications for obesity? Retatrutide is a next-generation “triple

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Cell Metab 2022;34:1064-78.e6.ArticlePubMedPMC 126

Key Findings: ~95% of dietary glutamate is metabolized in the small intestine ~50% is used for energy The remainder contributes to: Glutathione synthesis (antioxidant) Arginine synthesis (growth + immunity) Proline synthesis (tissue repair + gut structure) These findings imply that dietary glutamate plays an important functional role in the gut, well beyond its role in enhancing taste

Thomas N, Gurvich C, Huang K, Gooley PR, Armstrong CW