303 Interestingly, intracerebroventricular administration of GLP-1 did not inhibit feeding in GLP-1R knockout mice but did in wild-type mice, suggesting that GLP-1R signalling mediates satiety, although no evidence for abnormal body weight or feeding behaviour was reported in GLP-1R knockout mice
Retatrutide for pain Lilly also reported that trial participants saw "substantial relief" from osteoarthritis pain, another sign that these blockbuster drugs are treating more than obesity
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The SURMOUNT trial program involved large, diverse populations
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