As an example, based on the in-vitro study, in CRC cells, melatonin increases intracellular ROS levels, leading to oxidative stress-induced apoptosis and promoting autophagy through the endoplasmic reticulum (ER) stress pathway [186]
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Munshi A, Kurland JF, Nishikawa T, Chiao PJ, Andreeff M , Meyn RE
However, more research is needed to fully understand its effects on heart health and to determine the optimal dosages for its use