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GLP-1 RAs are generally considered to be a safe medication option, but serious side effects can occasionally occur

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SCFAs exert their effects by activating transmembrane G protein-coupled receptors and inhibiting histone acetylation (Li et al., 2017)

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Buprenorphine, also an opioid, also has a significant long-term side effect profile, including over 60% of patients reporting sleep disturbances that may interfere with treatment