In pratica - Gli agonisti del recettore del GLP-1 sono specificamente indicati in associazione con metformina (e/o un altro farmaco orale) in alcuni contesti clinici, per esempio per i pazienti con malattia cardiovascolare aterosclerotica esistente, con emoglobina glicata molto lontana dall'obiettivo, o quando importante perdere peso o evitare le ipoglicemie
We recently showed that concomitant administration of MDMA with ethanol resulted in markedly suppressed ALDH2 and ALDH1 activities with elevated blood levels of acetaldehyde (the quintessentially toxic primary metabolite of ethanol) and enhanced hepatotoxicity in rats [101]
This means it can improve cholesterol levels
However, some people continue having mild intermittent nausea or digestive issues even after months at the same dose
Some have additional proven benefits, such as protecting the heart or kidneys or treating obstructive sleep apnea
However, because phentermine is similar to stimulants, it is generally not recommended for long-term use
