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The sequences were as follows: H 1 : 5-TTT TTT- GT CTC TGA GAG TTT - S-S - TCT CAA GGA TCA CCG CAT CTC TCA GAG AC-3 H 2 : 5-TGA GAG ATG CGG TGA TCC TTG AGA CTA AGT TCT CAA GGA TCA CCG CAT-3 H 3 : 5-TCT CAA GGA T -FAM- CA CCG CAT CTC TCA ATG CGG T -BHQ- GA TCC TTG AGA ACT TAG-3 Apparatus and Characterization Fluorescence imaging was performed by a Leica TCS SP8 inverted confocal microscope (Leica, Germany)

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Thus, expectations for the overall magnitude of effect from a given agent might be modest when treating patients whose baseline A1c is 30 pioglitazone reduced HbA1c levels better than sitagliptin while in individuals with a BMI 90 canagliflozin lowered HbA1c better than sitagliptin while in individuals with an eGFR between 60-90 sitagliptin was more effective (13)

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