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We will follow up these athletes for five years with blood tests

The four most clinically relevant variants are GLP1R rs6923761 (appetite receptor sensitivity), GIPR rs1800437 (dual-pathway activation), FTO rs9939609 (metabolic set-point), and MC4R rs17782313 (appetite signaling)

Patients who combine GLP-1 therapy with dietary changes, regular physical activity, and behavioural strategies typically experience faster and more substantial improvements in both weight and glycaemic control

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In the absence of clinical trials for these substances, users rely on anecdotal evidence and self-experimentation to determine whether they are effective

Front Clin Diabetes Healthc 2023;4:1293926.PubMedPMC 5