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The success of these therapies has paved the way for the development of next-generation treatments, including multi-agonist molecules like Tirzepatide (Mounjaro/Zepbound) or Retatrutide (LY3437943) that simultaneously target several metabolic receptors to achieve improved metabolic outcomes in obese or diabetic patients [3,6]

This multi-layered crosstalk amplifies the regulatory signals from the gut microbiome, ensuring a robust and fine-tuned response to myocardial stress

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is derived from Semax ACTH(4-10) the central fragment of adrenocorticotropic hormone, a pituitary peptide