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Acknowledgments We would like to thank the authors of these original studies on this topic included in our review

Luna-MarcoCde MaraonAMHermo-ArgibayARodriguez-HernandezYHermenejildoJFernandez-ReyesMet al

We also sought comments on potential unintended consequences of the proposal, if any, including special considerations if needed to mitigate those potential consequences for certain hospitals

doi: 10.1016/j.bcp.2025.116797 171

MC4R activation triggers adenylate cyclase cAMP production modulation of downstream dopamine signaling