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Merrifield Resin 125 g (100mmol, 0.8mmol/g) is weighed, added to the compound 1 obtained above, reacted in N-methylpyrrolidone at 80 for 24 hours, filtered, the solid phase Resin is washed with DCM, then added with DCM solvent of 25% TFA and reacted at room temperature for 2 hours to obtain 1- (2-hydroxyethyl) imidazole Merrifield Resin without tert-butyl protection

However, few research institutions in this area can afford to use NHP models in their studies