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The combination therapy of metformin and CDDP weakens ERK-mediated phosphorylation of NRF2, enhances its polyubiquitination, and promotes its proteasomal degradation, thereby significantly reducing the levels of NRF2 in A549/DDP and H838 NSCLC cells, promoting ROS-mediated apoptosis

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Studies have also shown that heterozygosity in these loci, such as DRB1*03-DQB1*02/DRB1*0401-DQB1*0302, make it at least six times more likely to develop T1D compared to homozygosity for either haplotype (58, 60)

Jhang, L.-S

Three properties drive it: 1

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