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While the peptide appeared well tolerated in these trials, the absence of reproducible clinical benefit meant the molecule did not progress to approval or further late-stage studies

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This is especially relevant to individuals with poorly functioning GST enzymes

The ~10-15% weight reduction seen in trials represents excellent outcomes, but requires months of consistent administration

Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

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