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doi: 10.1016/j.tibtech.2023.10.001 189 ManciniAGentileMTPentimalliFCortellinoSGriecoMGiordanoA

Are not prepared for potential gastrointestinal side effects: GLP-1 medications commonly cause nausea, vomiting, diarrhea, and constipation, particularly during dose escalation periods

5-Amino-1MQ is a small, non-hormonal molecule that targets lipid metabolism via NNMT inhibition and NAD+ preservation, without affecting appetite

Pradalier et al

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Instead, its primary effects on weight and energy balance are mediated through appetite suppression and reduced caloric intake